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Single-cell atlas maps human prefrontal cortex gene activity across lifespan

Researchers create a population-scale transcriptomic atlas of the dorsolateral prefrontal cortex using samples from nearly 1,500 donors to reveal molecular changes in brain ageing and disease.

1 publisher · 4 articles · first seen 23 Sept 2026 · updated 2d ago

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How it unfolded

Every source in the order it published.

  1. NatureLifespan single-cell transcriptomic atlas of the human prefrontal cortex
  2. NatureSingle-cell atlas of transcriptomic vulnerability across brain disorders
  3. NatureLandmark map of human brain’s gene activity holds clues to Alzheimer’s disease and more
  4. NatureVast cellular gene-expression atlas could transform how scientists understand brain ageing and disease

Sources

Every article we clustered into this story. Headlines link to the publisher.

  1. Lifespan single-cell transcriptomic atlas of the human prefrontal cortex Nature ·
  2. Single-cell atlas of transcriptomic vulnerability across brain disorders Nature ·
  3. Landmark map of human brain’s gene activity holds clues to Alzheimer’s disease and more Nature ·
  4. Vast cellular gene-expression atlas could transform how scientists understand brain ageing and disease Nature ·

In this story

  • prefrontal cortex