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Prime assembly enables precise genomic integration without double-strand breaks

The technique allows RNA-guided insertion of large DNA sequences in human cells, supporting exon recoding and megabase-scale rearrangements.

2 publishers · 2 articles · first seen 16 Sept 2026 · updated 2h ago

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  1. Targeted genomic integration and rearrangement using prime assembly Nature ·
  2. Prime assembly can correct multiple mutations at once, pointing toward universal gene therapies Spotlight news only