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TRI-611 shows potential as brain-penetrant degrader for ALK-positive lung cancer

Preclinical data indicate the molecular glue degrades ALK fusion proteins via a novel CRBN motif, offering a new treatment avenue.

1 publisher · 1 article · first seen 9 Sept 2026 · updated 4d ago

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  1. TRI-611, a selective, brain-penetrant molecular glue degrader of ALK Nature ·

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  • TRI-611
  • ALK