Detroit Lions Defeat Arizona Cardinals 45-21 in Week 5 NFL Action
The Detroit Lions secured a decisive 45-21 victory over the Arizona Cardinals during their Week 5 matchup.
The story so far
2 publishers have covered this in 20 articles since 8 Oct 2026. SI Feed published first, on 8 October at 00:57 UTC; CBS Sports Headlines followed 80h 03m later. The most recent article, from SI Feed, appeared on 12 October at 13:32 UTC.
Outlets reporting it: SI Feed, CBS Sports Headlines.
One prediction market prices this story:
- Will the Arizona Cardinals win the 2027 NFL league championship? — the market puts it at 0%, with $24k traded in the last 24 hours, closing 1 Apr 2027. The Yes outcome occurs if the Arizona Cardinals win the 2027 NFL league championship. The No outcome applies if any other team wins or if the Cardinals are eliminated from contention before the title game is played. Readers often mistake the linked Week 4 power rankings for the final result, but only the actual championship winner matters.
Odds are the market's probability that the outcome happens, updated every few minutes. They are information about what traders expect, not a forecast we make and not investment advice.
How it unfolded
Every source in the order it published.
- SI FeedCardinals-Lions Official Week 5 Injury Report
- SI FeedCardinals Add Star Defender to Week 5 Injury Report vs Lions
- SI FeedCardinals vs Lions Week 5 Expert Picks, Prediction Roundup
- SI FeedDetroit Lions Rule Out Four Against Cardinals, DT Questionable
- SI FeedWalter Nolen Headlines Final Cardinals-Lions Week 5 Injury Report
- SI FeedSpot the Ball: 10 Thoughts Ahead of Lions Matchup Against Cardinals
- SI FeedHow To Watch, Listen, Stream Detroit Lions Against Arizona Cardinals
- SI Feed3 Lions Players Who Need to Bounce Back Against Cardinals
- CBS Sports HeadlinesLions vs. Cardinals odds, picks, prediction, spread, line: NFL Week 5 start time, betting preview, best bets
- SI FeedExpert Predictions For Detroit Lions Matchup With Arizona Cardinals
Show 10 later sources
- SI FeedDetroit Lions Week 5 Updated Depth Chart Against Cardinals
- SI FeedLions Insider Answers 5 Biggest Questions Ahead of Cardinals Week 5 Clash
- SI FeedCardinals vs. Lions: 3 Expert Bets to Target in Your Week 5 Parlay
- CBS Sports HeadlinesLions vs. Cardinals odds, picks, NFL Week 5 prediction, spread, line: start time, betting preview, best bets
- SI FeedRoundtable: Previewing Lions Week 5 Matchup Against Cardinals
- SI FeedKey Takeaways From Detroit Lions 45-21 Victory Over Arizona Cardinals
- SI Feed4 Big Instant Reactions After Cardinals' Humiliating Loss to Lions
- SI Feed8 Winners, 3 Losers From Lions’ Win Over Cardinals
- SI FeedDetroit Lions Grades: Offense Shakes Off Struggles, Mows Down Cardinals
- SI FeedDetroit Lions Snap Counts Against Cardinals Reveals DB Lost Job Again
Sources
Every article we clustered into this story. Headlines link to the publisher.
- Detroit Lions Snap Counts Against Cardinals Reveals DB Lost Job Again SI Feed
- Detroit Lions Grades: Offense Shakes Off Struggles, Mows Down Cardinals SI Feed
- 8 Winners, 3 Losers From Lions’ Win Over Cardinals SI Feed
- 4 Big Instant Reactions After Cardinals' Humiliating Loss to Lions SI Feed
- Key Takeaways From Detroit Lions 45-21 Victory Over Arizona Cardinals SI Feed
- Roundtable: Previewing Lions Week 5 Matchup Against Cardinals SI Feed
Show 14 more sources
- Lions vs. Cardinals odds, picks, NFL Week 5 prediction, spread, line: start time, betting preview, best bets CBS Sports Headlines
- Cardinals vs. Lions: 3 Expert Bets to Target in Your Week 5 Parlay SI Feed
- Lions Insider Answers 5 Biggest Questions Ahead of Cardinals Week 5 Clash SI Feed
- Detroit Lions Week 5 Updated Depth Chart Against Cardinals SI Feed
- Expert Predictions For Detroit Lions Matchup With Arizona Cardinals SI Feed
- Lions vs. Cardinals odds, picks, prediction, spread, line: NFL Week 5 start time, betting preview, best bets CBS Sports Headlines
- 3 Lions Players Who Need to Bounce Back Against Cardinals SI Feed
- How To Watch, Listen, Stream Detroit Lions Against Arizona Cardinals SI Feed
- Spot the Ball: 10 Thoughts Ahead of Lions Matchup Against Cardinals SI Feed
- Walter Nolen Headlines Final Cardinals-Lions Week 5 Injury Report SI Feed
- Detroit Lions Rule Out Four Against Cardinals, DT Questionable SI Feed
- Cardinals vs Lions Week 5 Expert Picks, Prediction Roundup SI Feed
- Cardinals Add Star Defender to Week 5 Injury Report vs Lions SI Feed
- Cardinals-Lions Official Week 5 Injury Report SI Feed
Markets on this story
- Polymarket Will the Arizona Cardinals win the 2027 NFL league championship? 0%
Does the market have this right?
Wrong market?