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H3K27M and ASCL1 maintain progenitor states in aggressive gliomas

Research reveals that the transcription factor ASCL1 cooperates with H3K27M to guide BRG1, keeping cells in an oligodendrocyte precursor state.

1 publisher · 1 article · first seen 10 Oct 2026 · updated 3d ago

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1 publisher has covered this in 1 article since 10 Oct 2026. Nature Communications published first, on 10 October at 00:00 UTC.

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  1. H3K27M cooperates with ASCL1 to maintain progenitor states and drive gliomagenesis Nature Communications ·
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